Can You Take NyQuil While on Seroquel?

Can You Take NyQuil While on Seroquel?
Published on, 30 May, 2024. Answered by Dr. Altin Tema and Verified by Dr.Galen Team
Patient Question

Hello Doctor,


I have been prescribed Seroquel for my insomnia. I take 50 mg every night at bedtime to help me sleep. Recently, I have become very sick, and in the past, NyQuil has always been very effective for me when I’m feeling under the weather. However, now that I am taking Seroquel, I am unsure if it is safe to take NyQuil as well. I know that medications can sometimes interact with each other in ways that could be harmful or cause unwanted side effects, and I certainly want to avoid any complications. Can you please advise me if it is safe to take NyQuil while I am on Seroquel? If there are any risks or interactions I should be aware of, I would greatly appreciate your guidance.


Answered by Dr. Altin Tema


Thank you for reaching out to Dr. Galen. Please find the below response to your query.


Your concern about taking NyQuil while being prescribed Seroquel for insomnia is valid. It is important to be aware of potential interactions between medications to avoid any adverse effects. NyQuil contains several components, including doxylamine, dextromethorphan, and other ingredients that can interact with Seroquel (quetiapine).


Firstly, doxylamine, an antihistamine present in NyQuil, can increase sedation when taken with Seroquel. Since Seroquel also has sedative properties, taking both together could lead to excessive drowsiness or sedation. It is crucial to use caution and monitor yourself closely if you decide to take NyQuil.


Secondly, dextromethorphan, a cough suppressant in NyQuil, may interact with Seroquel in an unspecified manner. This means that while we know there is an interaction, the exact nature of it is not fully understood. Therefore, caution and close monitoring are again advised if you choose to use NyQuil.


Additionally, serotonin modulators, which are sometimes part of cold medications, can enhance the dopamine blockade caused by antipsychotics like Seroquel. This interaction might increase the risk of developing neuroleptic malignant syndrome (NMS), a rare but serious condition characterized by hyperthermia (high fever), muscle rigidity, and autonomic dysfunction. Antipsychotics like Seroquel can also enhance the serotonergic effects of serotonin modulators, potentially leading to serotonin syndrome, another serious condition marked by symptoms such as mental status changes, autonomic instability, and neuromuscular hyperactivity.


Given these potential interactions, it is advisable to avoid taking NyQuil while on Seroquel without first consulting with your healthcare provider. They can provide personalized advice based on your specific health situation. If you are experiencing severe cold or flu symptoms, your doctor may be able to recommend alternative treatments that are safer to use with Seroquel.




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About Dr. Altin Tema

Dr. Altin Tema

Family Practice / General Practice

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