Hello Doctor,
I’ve been diagnosed with anti-GBM antibody disease and I’ve heard that certain HLA haplotypes might be linked to this condition. Could you please explain which HLA haplotype is most strongly associated with anti-GBM disease? I’m trying to understand how this might affect my treatment or prognosis.
Hello
Thank you for reaching out to Dr. Galen. Please find the below response to your query.
The HLA haplotype most strongly associated with anti-GBM antibody disease, particularly in cases of Goodpasture syndrome, is the HLADRB1*1501 allele. Studies have shown that individuals with this specific allele, along with the DRB1*1401 and DRB1*1101 alleles, are at a higher risk of developing anti-GBM disease.
These genetic markers are believed to play a role in the immune system’s response, increasing the likelihood of producing antibodies that target the glomerular basement membrane, leading to the damage seen in Goodpasture syndrome. Understanding these associations can be helpful in assessing the risk and guiding treatment approaches.
Thanks
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