Is It Safe to Take Sertraline and Trazodone Together?

Published on, 20 April, 2025. Answered by Dr. Claudine Christiaens and Verified by Dr.Galen Team
Patient Question

Hello Doctor,

 

I'm a 25-year-old female, and my doctor recently prescribed me 50mg of sertraline and 150mg of trazodone. After doing some research online, I came across information that suggests taking these two medications together might increase the risk of serotonin syndrome. I'm feeling a bit anxious about this but also hesitant to question my doctor's decision. Can you provide any insights on how safe it is to take them together? Should I be concerned about any specific symptoms or side effects?

 

Hello,

Thank you for reaching out to Dr. Galen. Please find the below response to your query.

 

1. The combination of sertraline and trazodone is sometimes prescribed for conditions such as depression, anxiety, or sleep disturbances. However, it’s important to understand the reason why your doctor chose this combination for you. While both medications affect serotonin levels, they can be used together under medical supervision.

 

2. Generally, if you have no kidney issues and do not have significantly low blood pressure, this combination is considered safe for many patients. However, you should be aware of potential side effects, such as dizziness, drowsiness, or changes in blood pressure. The main concern with combining these medications is the risk of serotonin syndrome, which, although rare, can present with symptoms like confusion, rapid heartbeat, excessive sweating, shivering, or muscle stiffness.

 

3. If you experience any unusual symptoms or feel unwell after starting these medications, it’s best to consult your doctor immediately. Always follow your prescribed dosage and avoid making changes without discussing it with your healthcare provider.

 

Thanks

 


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