Patient Question
Hello Doctor,
How does Alzheimer's disease progress in the brain, and what specific cellular and molecular changes occur during its development?
Answered by Dr. Prem Kumar Chandrasekaran
Hello,
Thank you for reaching out to Dr. Galen. Please find the below response to your query.
As Alzheimer's disease advances, it typically results in a steady decline, characterized by a reduction of 2 points in the Mini Mental State Examination score every 6 months. This progression is accompanied by structural shrinkage in the brain and the presence of neurofibrillary tangles and amyloid plaques. These pathological changes disrupt the function of acetylcholinesterase, a crucial neurotransmitter responsible for information transmission.
