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How to Treat Diabetes Insipidus?

Things to note:
Rehydration with water or hypotonic fluids.

Medical Treatment:
Replacement therapy
* Desmopression, oral, 0.2-1.2 mg daily.
  • Optimal dose: 0.1-0.2 mg 8 hourly.
Acute management
Post operatively:
  • Desmopressin, nasal spray, 10-20 mcg 12-24 hourly.
* Desmopressin, oral, 0.1 mg 8 hourly.
  • Adjust dose according to response to a maximum of 1.2 mg per day in divided doses.
  • Larger doses can lead to water overload and hyponatraemia.

When to refer:
  • Water deprivation is necessary to confirm the diagnosis. Careful monitoring of electrolytes and the exclusion of fluid overload during therapy is essential to determine the appropriate dose.