How to Treat Myasthenia Gravis?

  • December 29, 2023
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How to Treat Myasthenia Gravis?

What is Myasthenia Gravis?

Myasthenia Gravis (MG) is an autoimmune condition characterized by skeletal muscle weakness. This refers to the muscles that are connected to your bones, facilitating movement. The condition typically targets muscles in various areas of the body, including the eyes, face, neck, arms, and legs. The root cause of MG lies in the immune system's misguided attack on the neuromuscular junction, where nerve cells communicate with muscles. This assault disrupts the normal transmission of signals, resulting in weakness and fatigue, particularly evident in muscles responsible for eye and eyelid movement, facial expressions, chewing, swallowing, and speaking.

Why Does Myasthenia Gravis Occur?

The precise cause of Myasthenia Gravis remains elusive, but it is generally attributed to an autoimmune response. In individuals with MG, the immune system produces antibodies that target acetylcholine receptors on the surface of muscle cells. Acetylcholine is a neurotransmitter responsible for transmitting signals between nerve cells and muscles. When antibodies interfere with acetylcholine receptors, the transmission of signals becomes disrupted, leading to muscle weakness.

How Does Myasthenia Gravis Manifest?

The hallmark of Myasthenia Gravis is muscle weakness, which typically worsens with activity and improves with rest. The severity and distribution of weakness can vary widely among affected individuals. Common symptoms include drooping of the eyelids (ptosis), double vision (diplopia), difficulty in speaking, chewing, and swallowing, as well as weakness in the arms and legs.

The course of MG can be unpredictable, with symptoms fluctuating over time. Some individuals may experience periods of remission, where symptoms improve or disappear, while others may face persistent challenges. The variability in symptoms makes the management of Myasthenia Gravis a complex task.