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How to Treat Pagets Disease Of The Nipple?

  • November 10, 2023
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How to Treat Pagets Disease Of The Nipple?

What is Paget's Disease of the Nipple?

Paget's Disease of the Nipple, or Paget's disease of the breast, is a rare form of breast cancer that primarily affects the nipple and surrounding areola. Named after Sir James Paget, it involves changes in the nipple's skin, appearing red, scaly, and inflamed. Despite being localized, the disease often extends to the ducts beneath the skin, making diagnosis and treatment more complex than other breast cancers.

This rare breast cancer, also known as mammary Paget's disease, presents as stage 0 breast cancer confined to the nipple or coexists with invasive breast cancer in the milk ducts. It resembles eczema on the nipple, initially mistaken for a common rash, with symptoms such as itching, scaling, red plaques, and nipple discharge. While not everyone with these symptoms has Paget's disease, for those who do, they may signal an underlying breast cancer.

Why Does Paget's Disease Occur?

The exact cause of Paget's Disease of the Nipple remains unclear. However, it is widely believed to be associated with underlying breast cancer, particularly ductal carcinoma in situ (DCIS). DCIS is a non-invasive form of breast cancer that starts in the milk ducts and may progress to invasive cancer if left untreated. Paget's Disease is thought to occur when cancer cells from DCIS migrate to the surface of the nipple, causing the characteristic skin changes.


How is Paget's Disease Diagnosed and Staged?

Diagnosing Paget's Disease often involves a combination of clinical examination, imaging studies, and biopsy. The changes in the nipple and areola are typically visible during a physical examination. Mammograms, ultrasound, and magnetic resonance imaging (MRI) are commonly used to assess the extent of the disease within the breast. Additionally, a biopsy, where a small tissue sample is taken from the affected area, is essential to confirm the presence of cancer cells.

Staging Paget's Disease is crucial for determining the appropriate treatment strategy. The staging process considers the size of the tumor, whether lymph nodes are affected, and if the cancer has spread to other parts of the body. Stages range from 0 to IV, with lower stages indicating a localized disease and higher stages signifying more extensive involvement.

Treatment Solutions for Paget's Disease of the Nipple

  1. Surgery: The primary treatment for Paget's Disease involves surgery to remove the affected tissue. The two main surgical options are mastectomy and breast-conserving surgery. Mastectomy involves the removal of the entire breast, while breast-conserving surgery aims to remove the cancerous tissue while preserving the breast.
  2. Radiation Therapy: Radiation therapy is often recommended after surgery to target any remaining cancer cells and reduce the risk of recurrence. It involves the use of high-energy beams to destroy cancer cells. The decision to include radiation in the treatment plan depends on the extent of the disease and the type of surgery performed.
  3. Chemotherapy: For cases where Paget's Disease is associated with underlying invasive breast cancer, chemotherapy may be recommended. Chemotherapy uses drugs to kill or slow the growth of cancer cells and is administered either orally or intravenously. It is often used in conjunction with surgery and/or radiation therapy.
  4. Hormone Therapy: If the cancer is hormone receptor-positive, hormone therapy may be prescribed. This treatment involves blocking hormones that fuel the growth of certain types of breast cancer cells. It is commonly used in cases where the cancer is estrogen receptor-positive or progesterone receptor-positive.
  5. Targeted Therapy: Targeted therapy is a newer approach that focuses on specific molecules involved in cancer growth. HER2-positive breast cancers, which overexpress the HER2 protein, may be treated with targeted therapies such as trastuzumab (Herceptin).

Benefits of Treating Paget's Disease

  1. Improved Survival Rates: Early detection and prompt treatment of Paget's Disease of the Nipple are associated with better survival rates. Aggressive treatment measures, such as surgery and adjuvant therapies, contribute to reducing the risk of recurrence and improving overall outcomes.
  2. Preservation of Quality of Life: Advances in treatment options, including breast-conserving surgery and targeted therapies, aim to preserve the physical appearance of the breast while effectively treating the disease. This helps in maintaining the patient's quality of life and self-esteem.
  3. Reduced Risk of Recurrence: A comprehensive treatment approach, including surgery, radiation, and systemic therapies, is designed to target both the visible signs of Paget's Disease and any underlying cancer cells. This multifaceted strategy aims to reduce the risk of recurrence and enhance long-term outcomes.
  4. Individualized Treatment Plans: The complexity of Paget's Disease requires a personalized treatment plan based on the specific characteristics of the disease, including its stage, hormone receptor status, and HER2 status. Tailoring the treatment to the individual patient's needs increases the likelihood of successful outcomes.

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