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How to Treat Chordoma?

  • December 04, 2023
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How to Treat Chordoma?

What is Chordoma?

Chordoma, a rare cancer originating from fetal notochord remnants, typically emerges in the spine or the base of the skull, with a prevalence in adults. These slow-growing tumors often go unnoticed until reaching a considerable size or causing symptoms. Categorized as a rare malignant bone tumor, chordomas vary in occurrence, with approximately 35% in the sacrum, 35% in the spine-skull junction (clival chordomas), and 30% in the vertebrae of the mobile spine.

Chordomas, known for their recurrence and potential metastasis in 30% to 40% of cases, pose unique treatment challenges. Their slow growth and infiltration into adjacent nervous system tissues necessitate a carefully tailored, comprehensive approach for effective management.

Why is Chordoma Challenging to Treat?

Treating chordoma poses a unique set of challenges. One major obstacle is the location of the tumor. The spine and skull base are complex regions with critical structures such as nerves and blood vessels. The intricate nature of these structures makes surgical removal of chordomas difficult without causing significant damage to surrounding tissues.

Additionally, chordomas are known for their tendency to recur even after initial treatment. The cells of a chordoma can invade nearby tissues and may be resistant to conventional cancer treatments like chemotherapy and radiation therapy. This recurrent nature makes the management of chordoma an ongoing and often complex process.



How is Chordoma Treated?

The treatment approach for chordoma typically involves a combination of surgery, radiation therapy, and in some cases, targeted therapy.

  1. Surgery: Surgical removal of the tumor is often the primary treatment for chordoma. However, the location of the tumor can make complete removal challenging, and surgeons must balance the goal of removing as much of the tumor as possible while minimizing damage to surrounding structures. In cases where the tumor cannot be completely removed, surgery may still be performed to relieve symptoms or obtain a tissue sample for further analysis.
  2. Radiation Therapy: Radiation therapy is commonly used in conjunction with surgery to target any remaining cancer cells. High doses of radiation are focused on the tumor site to kill or damage cancer cells, preventing their growth and division. This approach helps reduce the risk of recurrence.
  3. Targeted Therapy: In recent years, researchers have been exploring targeted therapy options for chordoma. These therapies aim to interfere with specific molecules involved in the growth and survival of cancer cells. While targeted therapies may not be the primary treatment, they can be used in combination with surgery and radiation to improve outcomes.

Treatment Challenges and Considerations

  1. As research in the field of oncology advances, there is a growing interest in identifying novel treatment solutions for chordoma. Clinical trials are exploring the efficacy of new drugs and therapies, including immunotherapy, which harnesses the body's immune system to target and destroy cancer cells.
  2. Immunotherapy holds promise in treating chordoma by enhancing the body's natural defense mechanisms against cancer. By stimulating the immune system, these therapies aim to recognize and eliminate cancer cells, potentially offering a more targeted and less invasive approach compared to traditional treatments.
  3. While immunotherapy is still under investigation for chordoma, early results from clinical trials are encouraging. Researchers are optimistic that these emerging therapies could provide additional options for patients, especially those who may not respond well to conventional treatments.
  4. Despite advancements in treatment options, chordoma remains a challenging cancer to manage. The slow-growing nature of the tumor and its tendency to recur necessitate long-term monitoring and potential additional treatments. Furthermore, the impact of chordoma on a patient's quality of life cannot be understated, as the location of the tumor often leads to symptoms such as pain, difficulty swallowing, and neurological deficits.

Benefits of Integrative and Supportive Care

  1. Beyond medical treatments, integrative and supportive care plays a vital role in managing chordoma. Patients often experience physical and emotional challenges throughout their cancer journey, and supportive care aims to address these aspects.
  2. Integrative therapies, such as acupuncture, massage, and mindfulness practices, can help alleviate pain and improve overall well-being. Additionally, psychological support, including counseling and support groups, can assist patients and their families in coping with the emotional toll of a chordoma diagnosis.
  3. Given the complexities of chordoma treatment, a multidisciplinary approach is crucial. A team of healthcare professionals, including surgeons, radiation oncologists, medical oncologists, and supportive care specialists, collaborate to develop a comprehensive treatment plan tailored to the individual patient. This approach ensures that various aspects of the disease are addressed, leading to more effective and personalized care.


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